Intracellular recording of the membrane potential of a pyramidal neuron in the CA1 region of the hippocampus and an extracellular recording of the CA1 pyramidal layer local field potential during a sharp-wave ripple recorded from a freely behaving mouse. In orange is a different CA1 pyramidal neuron filled with biocytin during intracellular recording, and in blue DAPI staining
I am a neurophysiologist currently training as a postdoctoral fellow in the laboratory of Dr. Gyorgy Buzsaki at New York University. Previously I received my PhD from Rutgers University under the mentorship of Dr. Tibor Koos and Dr. James M. Tepper.
I am interested in how synaptic, cellular and network physiology interact to produce precisely timed neuronal and behavioral functions.
For my PhD thesis I combined optogenetic techniques with in vitro whole cell recordings and in vivo single unit recordings to discover novel cholinergic-GABAergic microcircuitry in the neostriatum.
GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons
English et al. 2012 Nature Neuroscience
During my postdoctoral work thus far I have applied intracellular sharp electrode recording techniques to freely moving mice, and used this novel technology to demonstrate how excitatory and inhibitory inputs to CA1 pyramidal neurons compete during sharp-wave ripple oscillations to control spiking.
Excitation and inhibition compete to control spiking during hippocampal ripples: intracellular study in behaving mice
English et al. 2014 Journal of Neuroscience
My Google Scholar
Link to Buzsaki Lab Website: http://www.buzsakilab.com